Insidon (Opipramol Dihydrochloride 50mg | 50 Tablets)

What is Insidon (Opipramol)?

Insidon is a tricyclic antidepressant used widely in Europe, primarily for anxiety-related disorders. Its active ingredient, Opipramol dihydrochloride, sets it apart from traditional antidepressants due to its unique mechanism of action — it works as a SIGMAR1 receptor agonist, not a monoamine reuptake inhibitor.

Key Benefits

• Reduces anxiety, nervousness, and tension

• Improves mood and sleep quality

• Effective for somatic symptoms without a clear medical cause

• Non-habit forming with low risk of dependency

• Suitable for long-term use under medical supervision

How Insidon Works

Unlike standard antidepressants, Insidon:

• Activates the sigma-1 receptors in the brain, improving emotional stability

• Has mild sedative effects through histamine receptor interaction

• Avoids the side effects typical of SSRIs or SNRIs due to its unique mechanism

Indications

Insidon is prescribed for:

• Generalized anxiety disorder (GAD)

• Mild to moderate depression with anxiety

• Psychosomatic disorders (e.g. IBS, cardiovascular tension, respiratory symptoms)

• Sleep disturbances caused by mental stress

• Somatoform and autonomic dysfunctions

Dosage and Administration

• Standard adult dosage: 50mg, 2–3 times daily

• Alternatively, 100mg at night may be recommended for sleep-related symptoms

• Tablets are taken orally with water, with or without food

• Always follow your doctor’s dosage instructions

Possible Side Effects

Most users tolerate Insidon well. Reported side effects may include:

• Mild drowsiness or dizziness

• Dry mouth

• Gastrointestinal discomfort

• Rare: skin reactions or elevated liver enzymes

Warnings & Precautions

• Not suitable for patients under 18

• Avoid alcohol and sedatives while taking Insidon

• Use with caution in elderly patients or those with liver/kidney issues

• Inform your doctor about any medications you are taking

Storage Information

• Store in a cool, dry place

• Keep away from heat and direct sunlight

• Keep out of reach of children

Manufacturer and Origin

Originally developed in 1961 by Schindler and Blattner, Insidon is produced today by various European pharmaceutical companies. It is a well-established treatment option with over 60 years of clinical use.

Final Notes

Insidon (Opipramol 50mg) is an effective and reliable option for managing anxiety, stress-related symptoms, and mood disorders—especially in patients who do not respond well to standard antidepressants. Its unique profile, safety in long-term use, and ability to improve overall quality of life make it a preferred choice among many practitioners.